Labcorp's cell line authentication testing division (formerly known as Genetica Cell Line Testing - a LabCorp brand), provides reliable, fast and affordable authentication of mouse cell lines, stem cell lines, xenografts, and more utilizing STR DNA technology; current clients include major research and cancer institutions, pharmaceutical and biotechnology companies within the United States and throughout the world.
Inadvertent cell line contamination has been a major problem for biomedical researchers with estimates that 18-36% of all cell lines are either misidentified or cross-contaminated with another cell line ; cell line integrity is of utmost importance since the validity of the data obtained often depends on the identity of the cell line or stem cells used. The National Institutes of Health  recommends validation of cell lines for grant applications and many journals such as those published by the American Association for Cancer Research (AACR)  and Nature have guidelines for cell line authentication prior to publication .
The short tandem repeat DNA profiling (STR DNA profiling, STR DNA typing, STR DNA test, and also known as DNA fingerprinting) offers the greatest value for mouse cell line identity verification (mouse cell line authentication). The process of obtaining a mouse DNA profile using highly polymorphic STR repeats includes the isolation of DNA from a mouse cell line or other research specimen, the amplification of targeted areas of that DNA, and analysis of the amplified product using a genetic analyzer. STR DNA typing generates reproducible data in a format suitable to mouse reference cell line database comparison. Labcorp's laboratory procedures for mouse cell line authentication comply with the guidelines set forth for human cell line authentication by the American Type Culture Collection (ATCC) SDO Workgroup ASN-0002 Standards document , as well as with the requirements and recommendations of other leading scientific organizations, including the National Institute of Standards and Technology (NIST) . A mouse cell line authentication Standards document has not yet been released and a statistical approach to mouse cell line authentication is under evaluation in the scientific community.
Labcorp provides reliable, fast, and affordable mouse cell line authentication services, using STR DNA typing to assist the scientific community in accurate identification of mouse specimens used in research and drug development. Our standard mouse cell line authentication test involves generating STR DNA profiles of the submitted cell lines or other research specimens for 18 independent genetic sites located in the mouse genome; the test also includes two HUMAN markers to detect cross-contamination with human specimens/cell lines (will also detect African Green Monkey cells/DNA).
At Labcorp, we make cell line authentication easy and affordable. Simply click on the "Pricing" tab for service costs, call us or submit a "Contact Us" form to get started. We will then assist you in setting up your mouse cell line authentication test.
Once we receive your samples, you will have your mouse cell line authentication report and/or data typically within 2-3 business days!
**Electropherogram data (peak data) is included FREE with every sample you submit**
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Ask your Labcorp cell line testing representative for DETAILED specimen preparation requirements and a copy of the Submission Form prior to shipping.
Fresh or frozen cell pellet:
Dried cell pellet:
Genomic DNA: We accept the DNA extract for testing at a reduced cost per sample.
Please put the DNA concentration of the sample on the Submission Form
If the sample you wish to submit is not listed above, please Contact Us or call us at 1-800-IDENTITY (433-6848) or (1-513-985-9777 INTL) to see if we can help you with your specific sample.
These steps are crucial to the success of the research project and to the acceptance of the research in the scientific community. Please refer to the suggested references for additional details on cell line authentication.
Labcorp is one of the most experienced providers of DNA identity testing services worldwide. As a leading DNA testing service provider, we are committed to providing our clients with high quality cell line authentication results delivered with unmatched service and satisfaction, product specialization and technical expertise.
Learn more by clicking on our "About Us" page.